abstract：:Extremely mild hypothermia to 36.0 °C is not thought to appreciably differ clinically from 37.0 °C. However, it is possible that 36.0 °C stimulates highly sensitive hypothermic signaling mechanism(s) and alters biochemistry. To the best of our knowledge, no such ultra-sensitive pathway/mechanisms have been described. ...

journal_title：Neuroscience

authors： Jackson TC,Manole MD,Kotermanski SE,Jackson EK,Clark RS,Kochanek PM

更新日期：2015-10-01 00:00:00

abstract：:The clinical differential diagnosis between the Parkinson variant of multiple system atrophy (MSA-P) and Parkinson's disease (PD) is difficult in early stages. To identify objective markers for differential diagnosis, we combined the novel tract-based spatial statistics (TBSS) and region of interest (ROI) analyses for...

journal_title：Neuroscience

authors： Ji L,Wang Y,Zhu D,Liu W,Shi J

更新日期：2015-10-01 00:00:00

abstract：:Sensory events in the space around us trigger specific motor patterns directed toward or away from the spatial location of the sensory source. Spatially-defined sensorimotor associations are well-known in the visual domain but less so for the auditory modality. In particular no spatially-directed audio-motor associati...

journal_title：Neuroscience

authors： Cattaneo L,Barchiesi G

更新日期：2015-09-24 00:00:00

abstract：:Vitamin D is a neuroactive steroid. Its genomic actions are mediated via the active form of vitamin D, 1,25(OH)2D3, binding to the vitamin D receptor (VDR). The VDR emerges in the rat mesencephalon at embryonic day 12, representing the peak period of dopaminergic cell birth. Our prior studies reveal that developmental...

journal_title：Neuroscience

authors： Cui X,Pertile R,Liu P,Eyles DW

更新日期：2015-09-24 00:00:00

abstract：:Icariin is derived most commonly from the traditional Chinese herb Epimedium brevicornum Maxim. Our previous studies have shown that icariin protects neurons from neurotoxic and ischemic conditions. This study aims to investigate the effect of icariin on the expression of amyloid precursor protein (APP) and the level ...

journal_title：Neuroscience

authors： Li F,Dong HX,Gong QH,Wu Q,Jin F,Shi JS

更新日期：2015-09-24 00:00:00

abstract：:Constraints involving the delivery method of glial cell line-derived neurotrophic factor (GDNF) have hampered its efficacy as a neuroprotectant in Parkinson's disease. Ex vivo gene therapy, in which suitable cells, such as bone marrow-derived mesenchymal stem cells (MSCs), are genetically engineered to overexpress GDN...

journal_title：Neuroscience

authors： Hoban DB,Howard L,Dowd E

更新日期：2015-09-10 00:00:00

abstract：:Maternal diabetes during pregnancy may increase the risk of neurodevelopmental disorders in the offspring by increasing inflammation. A major source of inflammatory signaling observed in diabetes is activation of the receptor for advanced glycation end-products (RAGE), and increased RAGE expression has been reported i...

journal_title：Neuroscience

authors： Chandna AR,Kuhlmann N,Bryce CA,Greba Q,Campanucci VA,Howland JG

更新日期：2015-09-10 00:00:00

abstract：:The incidence of asthma is more common in boys than in girls during the childhood, and more common in premenopausal female than age-matched males. Our previous study demonstrated a gender difference in histamine-mediated neuroexcitability in nodose ganglia neurons (NGNs), highlighting a possibility of histamine-mediat...

journal_title：Neuroscience

authors： Li JN,Li XL,He J,Wang JX,Zhao M,Liang XB,Zhao SY,Ma MN,Liu Y,Wang YB,Chen H,Qiao GF,Li BY

更新日期：2015-09-10 00:00:00

abstract：:Exposure to loud, prolonged sounds (acoustic trauma, AT) leads to the death of both inner and outer hair cells (IHCs and OHCs), death of neurons of the spiral ganglion and degeneration of the auditory nerve. The auditory nerve (8cn) projects to the three subdivisions of the cochlear nuclei (CN), the dorsal cochlear nu...

journal_title：Neuroscience

authors： Baizer JS,Wong KM,Manohar S,Hayes SH,Ding D,Dingman R,Salvi RJ

更新日期：2015-09-10 00:00:00

abstract：:Traditionally, multiple sclerosis (MS) is considered to be a disease primarily affecting the white matter (WM). However, the development of some clinical symptoms such as cognitive impairment cannot be fully explained by the severity of WM pathology alone. During the past decades it became clear that gray matter (GM) ...

journal_title：Neuroscience

authors： van Munster CE,Jonkman LE,Weinstein HC,Uitdehaag BM,Geurts JJ

更新日期：2015-09-10 00:00:00

abstract：:Neuronal differentiation is a critical developmental process that determines accurate synaptic connection and circuit wiring. A wide variety of naturally occurring compounds have been shown as promising drug leads for the generation and differentiation of neurons. Here we report that a diarylheptanoid from the plant A...

journal_title：Neuroscience

authors： Tang G,Dong X,Huang X,Huang XJ,Liu H,Wang Y,Ye WC,Shi L

更新日期：2015-09-10 00:00:00

abstract：:The goal of this research was to examine the effect of preconception paternal stress (PPS) on the subsequent neurodevelopment and behavior of male and female offspring. Prenatal (gestational) stress has been shown to alter brain morphology in the developing brain, and is presumed to be a factor in the development of s...

journal_title：Neuroscience

authors： Harker A,Raza S,Williamson K,Kolb B,Gibb R

更新日期：2015-09-10 00:00:00

abstract：:Although much prior work has focused on the known cortical pathology that defines Alzheimer's disease (AD) histologically, recent work has additionally demonstrated substantial damage to the cerebral white matter in this condition. While there is large evidence of diffuse damage to the white matter in AD, it is unclea...

journal_title：Neuroscience

authors： Lee SH,Coutu JP,Wilkens P,Yendiki A,Rosas HD,Salat DH,Alzheimer’s disease Neuroimaging Initiative (ADNI).

更新日期：2015-08-20 00:00:00

abstract：:Obesity may result from dysfunction of the reward system, especially in the nucleus accumbens (Acb). Based on this hypothesis, many researchers have tested the effect of high-frequency stimulation (HFS) of the Acb shell (Acb-Sh) and/or core (Acb-Co) on ingestive behaviors, but few studies have explored the possible me...

journal_title：Neuroscience

authors： Wei N,Wang Y,Wang X,He Z,Zhang M,Zhang X,Pan Y,Zhang J,Qin Z,Zhang K

更新日期：2015-08-20 00:00:00

abstract：:Among vertebrates hippocampus forms the major component of the brain in consolidating information from short-term memory to long-term memory. Aging is considered as the major risk factor for memory impairment in sporadic Alzheimer's disease (SAD) like pathology. Present study thus aims at investigating whether age-spe...

journal_title：Neuroscience

authors： Moorthi P,Premkumar P,Priyanka R,Jayachandran KS,Anusuyadevi M

更新日期：2015-08-20 00:00:00

abstract：:Probenecid has been used for decades to treat gout, and recent studies have revealed it is also a specific inhibitor of the pannexin-1 channel. It has been reported that the pannexin-1 channel is involved in ischemic injury. Here, we investigated the neuroprotective effect and the possible mechanisms of action of prob...

journal_title：Neuroscience

authors： Wei R,Wang J,Xu Y,Yin B,He F,Du Y,Peng G,Luo B

更新日期：2015-08-20 00:00:00

abstract：:The human brain is composed of complex networks of 100 billion neurons that underlie its higher functions. The set of neural connections in the brain has recently attracted growing interest from the scientific community. It is important to identify individual differences in these neural connections to study the backgr...

journal_title：Neuroscience

authors： Takao H,Hayashi N,Ohtomo K

更新日期：2015-08-20 00:00:00

abstract：:Properties of excitatory synaptic responses in fast-spiking interneurons (FSIs) and pyramidal neurons (PNs) are different; however, the mechanisms and determinants of this diversity have not been fully investigated. In the present study, voltage-clamp recording of miniature excitatory post-synaptic currents (mEPSCs) w...

journal_title：Neuroscience

authors： Malkin SL,Kim KK,Tikhonov DB,Magazanik LG,Zaitsev AV

更新日期：2015-08-20 00:00:00

abstract：:The presence of mRNAs in synaptic terminals and their regulated translation are important factors in neuronal communication and plasticity. Heterogeneous nuclear ribonucleoprotein (hnRNP) complexes are involved in the translocation, stability, and subcellular localization of mRNA and the regulation of its translation....

journal_title：Neuroscience

authors： Lico DT,Lopes GS,Brusco J,Rosa JC,Gould RM,De Giorgis JA,Larson RE

更新日期：2015-08-06 00:00:00

abstract：:Central GABA(A) receptors mediate GABAergic phasic and tonic inhibition. While synaptic αβγ GABA(A) receptors primarily mediate phasic inhibition, extrasynaptic αβδ receptors play an important role in mediating tonic inhibition. Etomidate is a general anesthetic that produces its effects by enhancing GABA(A) receptor ...

journal_title：Neuroscience

authors： Liu K,Jounaidi Y,Forman SA,Feng HJ

更新日期：2015-08-06 00:00:00

abstract：:Whereas activation of α1-adrenoceptors (α1-ARs) modulates glutamatergic transmission, the roles of α1-ARs in GABAergic transmission in the medial prefrontal cortex (mPFC) are elusive. Here, we examined the effects of the α1-AR agonist phenylephrine (Phe) on GABAergic transmission onto pyramidal neurons in the deep lay...

journal_title：Neuroscience

authors： Luo F,Tang H,Cheng ZY

更新日期：2015-08-06 00:00:00

abstract：:Western diets are high in fat and sucrose and can influence behavior and gut microbiota. There is growing evidence that altering the microbiome can influence the brain and behavior. This study was designed to determine whether diet-induced changes in the gut microbiota could contribute to alterations in anxiety, memor...

journal_title：Neuroscience

authors： Magnusson KR,Hauck L,Jeffrey BM,Elias V,Humphrey A,Nath R,Perrone A,Bermudez LE

更新日期：2015-08-06 00:00:00

abstract：:Endocannabinoids modulate a diverse array of functions including progenitor cell proliferation in the central nervous system, and odorant detection and food intake in the mammalian central olfactory system and larval Xenopus laevis peripheral olfactory system. However, the presence and role of endocannabinoids in the ...

journal_title：Neuroscience

authors： Hutch CR,Hillard CJ,Jia C,Hegg CC

更新日期：2015-08-06 00:00:00

abstract：:Updating the position of an earth-fixed target during whole-body rotation seems to rely on cognitive processes such as the utilization of external feedback. According to perceptual learning models, improvement in performance can also occur without external feedback. The aim of this study was to assess spatial updating...

journal_title：Neuroscience

authors： Mackrous I,Simoneau M

更新日期：2015-08-06 00:00:00

abstract：:We have recently reported on the efficacy of an N-methyl-d-aspartate (NMDA) receptor partial antagonist, S-Methyl-N,N-diethylthiolcarbamate sulfoxide (DETC-MeSO), in improving outcome following stroke, including reduced infarct size and calcium influx, suppressing the endoplasmic reticulum (ER) stress-induced apoptosi...

journal_title：Neuroscience

authors： Gharibani P,Modi J,Menzie J,Alexandrescu A,Ma Z,Tao R,Prentice H,Wu JY

更新日期：2015-08-06 00:00:00

abstract：:Group I metabotropic glutamate receptors (mGluR1 and mGluR5) are functionally linked to estrogen receptors and play a key role in the plasticity of central neurons. Estrogen status strongly influences sensory input from the temporomandibular joint (TMJ) to neurons at the spinomedullary (Vc/C1-2) region. This study tes...

journal_title：Neuroscience

authors： Tashiro A,Nishida Y,Bereiter DA

更新日期：2015-07-23 00:00:00

abstract：:Previous research has demonstrated antidepressant-like effects in rodents upon intracerebral inhibition of histone deacetylases (HDACs). Such effects have been reported for local HDAC inhibition in the nucleus accumbens, hippocampus, and amygdala. However, the effect of HDAC inhibition within the medial prefrontal cor...

journal_title：Neuroscience

authors： Covington HE 3rd,Maze I,Vialou V,Nestler EJ

更新日期：2015-07-09 00:00:00

abstract：:Estradiol-induced plasticity involves changes in dendritic spine density and in the relative proportions of the different dendritic spine types that influence neurons and neural circuits. Such events affect brain structures that control the timing of neuroendocrine and behavioral processes, influencing both reproducti...

journal_title：Neuroscience

authors： González-Burgos I,Velázquez-Zamora DA,González-Tapia D,Cervantes M

更新日期：2015-07-09 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder for which there is currently no effective treatment. Studies indicate that enhancing autophagy in mouse models of neurodegenerative disease can ameliorate the behavioral symptoms and pathological damage associated with the accumulation of pathol...

journal_title：Neuroscience

authors： Li Y,Guo Y,Wang X,Yu X,Duan W,Hong K,Wang J,Han H,Li C

更新日期：2015-07-09 00:00:00

abstract：:This study used the framework of the referent configuration hypothesis and slow changes in the external conditions during vertical oscillation of a hand-held object to infer the characteristics of hypothetical control variables. The study had two main objectives: (1) to show that hypothetical control variables, namely...

journal_title：Neuroscience

authors： Ambike S,Zhou T,Zatsiorsky VM,Latash ML

更新日期：2015-07-09 00:00:00

abstract：:The role of the cerebral cortex in maintaining human standing balance remains unclear. Beta corticomuscular coherence (CMC) provides a measure of communication between the sensory-motor cortex and muscle, but past literature has not demonstrated significant beta CMC during human stance. This study evaluated the effect...

journal_title：Neuroscience

authors： Jacobs JV,Wu G,Kelly KM

更新日期：2015-07-09 00:00:00

abstract：:Several studies reveal that the beneficial effects of exercise interventions are dependent on the progression of Alzheimer's disease (AD). We have previously shown that long-term treadmill exercise begun before the onset of β-amyloid (Aβ) pathology prevents the deficits of cognition and long-term potentiation (LTP) in...

journal_title：Neuroscience

authors： Zhao G,Liu HL,Zhang H,Tong XJ

更新日期：2015-07-09 00:00:00

abstract：:Prialt, a synthetic version of Ca(v)2.2 antagonist ω-conotoxin MVIIA derived from Conus magus, is the first clinically approved voltage-gated calcium channel blocker for refractory chronic pain. However, due to the narrow therapeutic window and considerable side effects associated with systemic dosing, Prialt is only ...

journal_title：Neuroscience

authors： Patel R,Rutten K,Valdor M,Schiene K,Wigge S,Schunk S,Damann N,Christoph T,Dickenson AH

更新日期：2015-06-25 00:00:00

abstract：:Neural function within the medial prefrontal cortex (mPFC) regulates normal cognition, attention and impulse control, implicating neuroregulatory abnormalities within this region in mental dysfunction related to schizophrenia, depression and drug abuse. Both serotonin-2A (5-HT2A) and -2C (5-HT2C) receptors are known t...

journal_title：Neuroscience

authors： Nocjar C,Alex KD,Sonneborn A,Abbas AI,Roth BL,Pehek EA

更新日期：2015-06-25 00:00:00

abstract：:A wide variety of species are used for the study of visual neuroscience. This is beneficial because fundamental mechanisms and theoretical principles of vision are likely to be highly conserved, while different species exhibit different visual capacities and present different technical advantages for experiments. Eigh...

journal_title：Neuroscience

authors： Reinagel P

更新日期：2015-06-18 00:00:00

abstract：:Following intracerebral hemorrhage (ICH), high-mobility group box 1 protein (HMGB1) may promote vascular remodeling. Whether HMGB1 supports angiogenesis after ICH is unclear, as are the receptors and downstream signaling pathway(s) involved. We used the rat model of collagenase-induced ICH to determine whether HMGB1 a...

journal_title：Neuroscience

authors： Lei C,Zhang S,Cao T,Tao W,Liu M,Wu B

更新日期：2015-06-04 00:00:00

abstract：:Exercise reduces the risk of developing a number of neurological disorders and increases the efficiency of cellular energy production. However, overly strenuous exercise produces oxidative stress. Proper oxygenation is crucial for the health of all tissues, and tight regulation of cellular oxygen is critical to balanc...

journal_title：Neuroscience

authors： Smeyne M,Sladen P,Jiao Y,Dragatsis I,Smeyne RJ

更新日期：2015-06-04 00:00:00

abstract：:Serotonin (5-HT) is a key regulator of mood and sexual behaviors. 5-HT reuptake inhibitors have been used as antidepressants. Really interesting new gene (RING) finger proteins have been associated with 5-HT regulation but their role remains largely unknown. Some RING finger proteins are involved in the serotonergic s...

journal_title：Neuroscience

authors： Moriya S,Khel NB,Parhar IS

更新日期：2015-05-21 00:00:00

abstract：:The amygdalar basolateral nuclear complex (BLC) is a cortex-like structure that receives inputs from many cortical areas. It has long been assumed that cortico-amygdalar projections, as well as inter-areal intracortical connections, arise from cortical pyramidal cells. However, recent studies have shown that GABAergic...

journal_title：Neuroscience

authors： McDonald AJ,Zaric V

更新日期：2015-05-21 00:00:00

abstract：:Motor commands issued by the CNS are based upon memories of past experiences with similar objects, the current state of the hand and arm postures, and sensory input. Thus widespread somatosensory information is available to form precise representations of hand shape on which to base motor commands to match a desired p...

journal_title：Neuroscience

authors： Winges SA

更新日期：2015-05-07 00:00:00